Plasma cholinesterase activity following administration of glycopyrrolate or atropine

Plasma pharmacokinetics of pioglitazone following oral or intravenous administration in Holstein cows

Pioglitazone belongs to the thiazolidinedione (TZD) class of antidiabetic agents, with proven efficacy in increasing insulin sensitivity and in the treatment of type 2 diabetes mellitus in humans. Pioglitazone has been proposed as a potential feed additive to reduce insulin resistance and consequently some of the metabolic disorders in transition cows. This study was aimed at determining the ph...

Pharmacokinetics of glycopyrrolate following intravenous administration in the horse.

Glycopyrrolate, designated a class 3 substance by the Association of Racing Commissioners International, Inc., is regulated in racing horses because of its potential to affect performance. Although it has veterinary clinical applications by inhibiting parasympathetic activity, its use near race day is prohibited and positive reports from postrace samples in the US are relatively common. Accordi...

Spectrophotometric micromethod for measuring cholinesterase activity in serum or plasma.

A simple ultraviolet method has been developed for determining serum or plasma cholinesterase activity. The cholinesterase acts on acetylor butyrylthiocholine to release thiocholine, which reacts with 2,2’or 4,4’-dithiodipyridine, showing absorbance at 324 or 343 nm, respectively. The activity can be measured kinetically and alsoafter incubation for 3 to 5 mm at 20#{176} to 37#{176}C. A volume ...

Comparison of the effects of atropine and glycopyrrolate on cognitive function following general anaesthesia.

Tests of orientation, concentration and short-term visual memory were used to assess 72 patients 1 day before, and 2 days after, elective major surgery. Patients were premedicated with papaveretum and either atropine or glycopyrrolate, before receiving a standard general anaesthetic. Those who had received atropine showed significant postoperative short-term memory deficit (P less than 0.01), b...

Cardiovascular effects of atropine and glycopyrrolate on anesthetized children.